- Sorafenib Treatment in Advanced Hepatocellular Carcinoma with Tumor Thrombus Nearly Occupying the Entire Right Atrium
-
Kang, Young Mo , Ryu, Soo Hyung , Lee, Bo Kyung , Ko, Kyoung Ho , Park, Tae Young , Moon, Jeong Seop , Cho, Seon Hwa
-
J Liver Cancer. 2018;18(2):142-145. Published online September 30, 2018
-
DOI: https://doi.org/10.17998/jlc.18.2.142
-
-
2,427
Views
-
36
Downloads
-
3
Citations
-
Abstract
PDF
- Advanced hepatocellular carcinoma (HCC) with tumor thrombus extending through the hepatic veins, inferior vena cava, and right atrium (RA) is very rare. However, whether active treatments such as radiation, transcatheter arterial chemoembolization, and sorafenib in advanced HCC with RA involvement prolong survival is uncertain. We present a rare case of advanced HCC with tumor thrombus nearly occupying the entire RA that was treated with sorafenib. The patient received 400 mg sorafenib twice daily. However, her liver enzyme levels continued to increase and abdominal computed tomography showed an increase in the tumor size in the liver and RA.
In the present case, active treatment with sorafenib was ineffective; thus, palliative care may be more beneficial in advanced HCC with extensive RA involvement.
-
Citations
Citations to this article as recorded by
- Hepatocellular Carcinoma with Hepatic Vein and Inferior Vena Cava Invasion
Akash Shukla, Abhinav Jain Journal of Clinical and Experimental Hepatology.2023; 13(5): 813. CrossRef - Clinical outcome and toxicity of radiotherapy for inferior vena cava tumor thrombus in HCC patients
So Jung Lee, Hong Seok Jang, Yoo Kyung Choi Medicine.2021; 100(25): e26390. CrossRef - miR-4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A
Haoming Lin, Rui Zhang, Wenrui Wu, Liming Lei, Grzegorz Węgrzyn Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef
|